GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs5758659 | 1 | rs5758677 | chr22:42643039 | NAGA | chr22:42454339-42466846:- | 0.31 | 5.58 | 4.52E-8 | Cognitive function |
| BLCA | cis | rs8141797 | 1 | rs5760216 | chr22:24539734 | SUSD2 | chr22:24577444-24585074:+ | 0.56 | 5.48 | 7.54E-8 | Amyotrophic lateral sclerosis |
| BLCA | cis | rs8141797 | 1 | rs5760220 | chr22:24542480 | SUSD2 | chr22:24577444-24585074:+ | 0.65 | 6.09 | 2.69E-9 | Amyotrophic lateral sclerosis |
| BLCA | cis | rs8141797 | 1 | rs5760229 | chr22:24560254 | SUSD2 | chr22:24577444-24585074:+ | 0.56 | 5.44 | 9.62E-8 | Amyotrophic lateral sclerosis |
| BLCA | cis | rs2412980 | 1 | rs5763855 | chr22:30578964 | NIPSNAP1 | chr22:29950800-29977144:- | -0.4 | -3.95 | 9.2E-5 | Dialysis-related mortality |
| BLCA | cis | rs2412980 | 1 | rs5763858 | chr22:30579722 | NIPSNAP1 | chr22:29950800-29977144:- | -0.42 | -4.16 | 3.97E-5 | Dialysis-related mortality |
| BLCA | cis | rs5770917 | 1 | rs5770922 | chr22:51023408 | CPT1B | chr22:51007291-51017096:- | -0.38 | -3.89 | 0.000119 | Narcolepsy |
| BLCA | cis | rs5770917 | 1 | rs5770924 | chr22:51024542 | CPT1B | chr22:51007291-51017096:- | -0.38 | -3.85 | 0.000139 | Narcolepsy |
| BLCA | cis | rs477692 | 1 | rs577227 | chr10:131404528 | MGMT | chr10:131265454-131565783:+ | 0.21 | 4.44 | 1.18E-5 | Response to temozolomide |
| BLCA | cis | rs8102137 | 1 | rs57894940 | chr19:30293462 | CCNE1 | chr19:30302901-30315218:+ | 0.21 | 3.97 | 8.72E-5 | Bladder cancer |
| BLCA | cis | rs7112513 | 1 | rs579890 | chr11:116798963 | PCSK7 | chr11:117075789-117102811:- | -0.38 | -4.61 | 5.41E-6 | Protein quantitative trait loci |
| BLCA | cis | rs2243480 | 1 | rs58062456 | chr7:65394852 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.38 | 1.53E-5 | Diabetic kidney disease |
| BLCA | cis | rs477692 | 1 | rs580745 | chr10:131414401 | MGMT | chr10:131265454-131565783:+ | 0.21 | 4.46 | 1.06E-5 | Response to temozolomide |
| BLCA | cis | rs9322193 | 1 | rs58189451 | chr6:149921388 | NUP43 | chr6:150045453-150067688:- | -0.27 | -4.27 | 2.51E-5 | Lung cancer |
| BLCA | cis | rs12908161 | 1 | rs58416181 | chr15:85264461 | LOC388152 | chr15:84867600-84898920:- | -0.23 | -4 | 7.56E-5 | Schizophrenia |